Aricept delivery system depends on the form of a medication, Aricept extended-release tablets have gradual release of the main component. Aricept extended-release tablets show peak plasma levels within 6-9 hours post dose in comparison with Aricept film-coated tablets (3-4 hours post dose). The peak plasma levels for Aricept film-coated tablets are lower than for Aricept immediate release tablets. Aricept medication is well-absorbed in the body, the food does not produce any reducing effect on the absorption of the medication. Aricept can be taken with or without food.
The elimination half-life of Aricept is approximately 70 hours, so the medication can be taken once a day. Aricept accumulates in plasma and reaches the steady state within 15 days.
Aricept has four major metabolites. The medication is eliminated in the urine. The elimination of the medication is decreased in patients with hepatic problems. Patients with kidney impairment do not have any differences in the clearance of the drug from other patients.
According to the studies of Aricept, the medication has practically the same pharmacokinetic parameters in patients of different ages, races and genders.
This dose of Aricept does not work the same in all patients. Some man may stay the same or seem that get worse over time but slower than expected or seem get better in small ways.
This drug is not for patients with Alzheimer’s disease. All people with this disease get worse over time.
The dose 23 mg may longer to work or take several weeks.
More people who used the dose 23 mg had more side effects, than people who used ARICEPT 10 mg. Many more patients taking this drug 23 mg experienced vomiting and nausea, than man taking this drug 10 mg. Other side effects that were seen more often with dose 23 mg were gastrointestinal bleeding/stomach ulcers/weight loss.
But when men took it continuously for one to three weeks, vomiting and nausea subsided.
The patient may have allergy to this drug, because if you noticed the next condition call your provider or specialist of health, the doctor may to do special tests or regulate a dose:
- a history of stomach ulcers;
- seizure disorder (epilepsy or other ); or
- an urination problems or enlarged prostate;
- COPD-chronic obstructive pulmonary disease or asthma;
- slow heartbeats: a heart rhythm disorder (“sick sinus syndrome”).
Do not take this drug if you are allergic to donepezil.
The serious side effects of Aricept may include the next symptoms:
• vomit or coughing up blood that looks like coffee grounds or blood ;
• convulsions or black-out (seizure);
• difficult or painful urination;
• tarry, bloody or black stools;
Also symptoms may be less serious, such as:
• diarrhea, loss of appetite;
• muscle cramps;
• vomiting; or
• tired feeling.
If the patient wants to take Aricept, he must call a doctor and tell him about all drugs which he use:
- atropine (Donnatal, and others);
- carbamazepine (Tegretol);
- rifampin (Rifamate, Rifadin, Rifater);
- dexamethasone (Decadron);
- clidinium (Quarzan);
- dicyclomine (Bentyl)
- phenytoin (Dilantin);quinidine (Quinidex, Cardioquin, Quinaglute, others);
- a fungal antibiotic: itraconazole (Sporanox), fluconazole (Diflucan),ketoconazole (Nizoral);
- hyoscyamine (Cystospaz, Levsin, Anaspaz and others);
- glycopyrrolate (Robinul);
- aspirin or other NSAIDs
- methantheline (Provocholine);
- mepenzolate (Cantil);
- scopolamine (Transderm-Scop);
- methscopolamine (Pamine),
- phenobarbital ( Solfoton, Luminal);
- propantheline (Pro-Banthine);
You have serious side effects:
• bloody,tarry stools, black ;
•vomit that looks like coffee grounds or blood
• difficult/painful urination;
• coughing up blood ;
• seizure ;
Less serious side effects :
• diarrhea, nausea ;
• muscle cramps;
• loss of appetite,vomiting;
• sleep problems (insomnia);
• tired feeling.
Brand Aricept is produced by Eisai Co. Ltd, Kawashima, Japan. The medication is marketed and promoted by Pfizer, the partner of Eisai.
Generic Aricept is developed and produced by the following credible manufacturers:
- Greenstone, LLC
- Ranbaxy Pharmaceuticals, Inc.
- Teva Pharmaceuticals USA
- UDL Laboratories.
The brand and generic versions of Aricept differ by inactive components in the formulation of the drugs. The active component donepezil is the same in the brand and generic medications.
Brand Aricept is manufactured in the form of film-coated tablets (Aricept) and orally disintegrating tablets (Aricept ODT) for oral administration.
Film-coated tablets of Aricept are available in the dosages of 5, 10 and 23 mg, packed in the bottles of 30 or 90 tablets.
Aricept ODT is available in the dosages of 5 and 10 mg tablets, packed in the bottles of 30 or 90 tablets.
Generic versions of Aricept are available in the form of film-coated tablets and oral disintegrating tablets in the doses of 5 and 10 mg tablets.
Generic Aricept tablets have undergone special clinical tests for safe use in patients for whom they are indicated. Generic Aricept is equivalent to the brand-name Aricept, but costs less.
All generic Aricept medications are rated as “AB” by the FDA (the Food and Drug Administration of the U.S.) meaning that they are absolutely equivalent to the brand Aricept.
Aricept (Donepezil) is an acetylcholinesterase inhibitor, medication used in the treatment of dementia caused by mild to moderate Alzheimer’s disease.
Aricept easily crosses the blood-brain barrier and stimulates the function of nerve cells in the brain and prevents the destruction of acetylcholine, a chemical substance in brain which low levels can impair the intellectual activity, the ability of people to think and memorize. The defects in cholinergic neurotransmission are suggested to be the cause of certain symptoms of Alzheimer’s disease. Aricept improves cholinergic function. The medication has a potential to increase the concentration of acetylcholine by inhibition acetylcholinesterase which is known to lower the levels of acetylcholine.
Aricept is a prescription medication, produced in the form of tablets: film-coated and extended release tablets prescribed for once daily use. The brand medication is manufactured by Eisai and Pfizer as a marketing and promoting partner.